Selenium species-dependent toxicity, bioavailability and metabolic transformations in Caenorhabditis elegans

Genetic and Pharmacologic analysis of the Mechanisms of Selenium toxicity in Caenorhabditis elegans by

Impact of sulfidation on the bioavailability and toxicity of silver nanoparticles to Caenorhabditis elegans.

Sulfidation is a major transformation product for manufactured silver nanoparticles (Ag-MNPs) in the wastewater treatment process.We studied the dissolution, uptake, and toxicity of Ag-MNP and sulfidized Ag-MNPs (sAg-MNPs) to a model soil organism, Caenorhabditis elegans. Our results show that reproduction was the most sensitive endpoint tested for both Ag-MNPs and sAg-MNPs. We also demonstrate...

TRANSFORMATIONS, BIOAVAILABILITY AND TOXICITY OF MANUFACTURED ZnO NANOMATERIALS IN WASTEWTER

OF THESIS TRANSFORMATIONS, BIOAVAILABILITY AND TOXICITY OF MANUFACTURED ZnO NANOMATERIALS IN WASTEWTER In order to properly evaluate the ecological and human health risks of ZnO Manufactured nanomaterials (MNMs) released to the environment, it is critical to understand the likely transformation products in the wastewater treatment process and in soils receiving biosolids. To address this critic...

An in vitro investigation of species-dependent intestinal transport of selenium and the impact of this process on selenium bioavailability.

A range of Se species has been shown to occur in a variety of different foodstuffs. Depending on its speciation, Se is more or less bioavailable to human subjects. In the present study, the role of speciation as a determinant of Se bioavailability was addressed with an investigation of species-specific mechanisms of transport at the intestinal level. The present work focused on four distinct Se...

Histidine Protects Against Zinc and Nickel Toxicity in Caenorhabditis elegans

Zinc is an essential trace element involved in a wide range of biological processes and human diseases. Zinc excess is deleterious, and animals require mechanisms to protect against zinc toxicity. To identify genes that modulate zinc tolerance, we performed a forward genetic screen for Caenorhabditis elegans mutants that were resistant to zinc toxicity. Here we demonstrate that mutations of the...